Description
buy rad-140 powder online
Testolone is a type of chemical known as a selective androgen receptor modulator (SARM). It mimics the activity of testosterone in the body. buy rad-140 powder online.
People use testolone to improve athletic performance and muscle strength, for breast cancer, and for other purposes, but there is no good scientific evidence to support these uses. Testolone might also be unsafe.
Effects on the body mass of animals buy rad-140 powder online
RAD 140 SARM, chemically known as (2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile) and also referred to as testolone, was originally synthesized by Radius Health Inc. in collaboration with researchers from the University of Illinois, Obiter Research, and Cambridge Major Laboratories.
According to the first study describing the synthesis and preliminary findings of the substance, RAD140 exhibits a high stability (with a half-life of more than 2 hours) in incubations with rat and monkey microsomes. It also has a high affinity for the androgen receptor (with a Ki of 7 nM), about four times higher than that of testosterone itself. At the same time, the closest hormone receptor activated by RAD140 was progesterone, at a level of 750 nM.
Early studies in primates showed that even at the lowest dosage of 0.1 mg/kg, young macaques gained an average of 10% body weight over a trial period of 28 days. This increase was primarily confirmed as lean mass, as indicated by DEXA scans performed before and after the trial period. However, these results were somewhat variable.
Effects on neurons buy rad-140 powder online
In a study conducted by Jayaraman et al., castrated male rats were examined to determine the neuroprotective effects of RAD 140 supplementation. This with a view to potential applications of SARMs against neurodegenerative disorders.
The rats were administered 1 mg/kg of RAD 140 orally daily for two weeks. It was found that RAD140 was able to significantly reduce apoptosis caused by Aβ, apoptosis-activator II, and hydrogen peroxide. This is attributed to the role that MAPK signaling plays in neuroprotection.
Aβ was by far the most potent trigger for apoptosis administered to the rats. After 24 hours of exposure to Aβ, the number of viable neurons in the rats decreased by 50%. However, when RAD 140 was administered in a concentration-dependent manner, the viability of the neurons increased exponentially. The most effective concentration of RAD 140 was 100 nM, which led to approximately 90% survival of neurons after Aβ exposure (Source).
“In addition to measuring the neuroprotective effects against various forms of apoptosis, the researchers also investigated the effects of RAD 140 on kainic acid-induced neuronal death. It was found that this form of neuronal death was significantly reduced compared to a control group (Source).”
🧪 Contents buy rad-140 powder online
The jar contains 1 gram of pure RAD-140 powder.
A measuring scoop is not included.
“For an accurate assessment, we recommend using a precision scale.”
Disclaimer
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